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KMID : 1123920110250061039
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Korean Journal of Oriental Physiology and Pathology
2011 Volume.25 No. 6 p.1039 ~ p.1043
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Effect of Emodin on Hydrogen Peroxide Production in Polyinosinic-Polycytidylic acid-induced Human Neuroblastoma SH-SY5Y Cells
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Lee Ji-Young
Kim Young-Jin
Park Wan-Su
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Abstract
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The purpose of this study is to investigate the modulatory effect of emodin on hydrogen peroxide production in human blastoma SH-SY5Y cells induced by the synthetic analog of double-stranded RNA [polyinosinic-polycytidylic acid]. Hydrogen peroxide production was measured by dihydrorhodamine 123 (DHR) assay. Emodin significantly inhibited the polyinosinic-polycytidylic acid (PIC)-induced production of hydrogen peroxide for 0.5, 2, 12, 18, and 24 hr incubation at the concentrations of 5, 10, 25, and 50 uM in SH-SY5Y (P < 0.05) in dose dependent manner. These results suggest that emodin has neuroprotective property related with its inhibition of hydrogen peroxide production in PIC-induced neuronal cells.
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KEYWORD
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emodin, neuronal cells, dsRNA, hydrogen peroxide, neuroprotective effect
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